Ovarian germ cell tumors with rhabdomyosarcomatous components and later development of growing teratoma syndrome: a case report

Ovarian germ cell tumors with rhabdomyosarcomatous components and later development of growing teratoma syndrome: a case report

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Abstract Introduction read more Development of a sarcomatous component in a germ cell tumor is an uncommon phenomenon.Most cases reported have a grim prognosis.Growing teratoma syndrome is also an uncommon phenomenon and occurs in approximately 2% to 7% of non seminomatous germ cell tumors and should be treated surgically.

Case presentation We report the case of a 12-year-old Asian girl with an ovarian mixed germ cell tumor containing a rhabdomyosarcomatous component.She was treated with a germ cell tumor chemotherapy regimen and rhabdomyosarcoma-specific chemotherapy.Towards the end of her treatment, she developed a retroperitoneal mass that was increasing in size.

It was completely resected, revealing a mature teratoma, consistent with growing teratoma syndrome.She is still in complete remission approximately three years after presentation.Conclusion The presence of rhabdomyosarcoma in a germ cell tumor should be treated by a combined chemotherapy regimen (for germ cell tumor and rhabdomyosarcoma).

In addition, development of a mass during sara stedy stand aid or after therapy with normal serum markers should raise the possibility of growing teratoma syndrome that should be treated surgically.